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Chapter 14: Problem 8

Pyruvate carboxylase is often considered a gluconeogenic enzyme; however, it also plays an important role in an energy-converting pathway under conditions of low energy charge and high acetyl-CoA levels in mitochondria. What is the name of this pathway?

Short Answer

Expert verified
Answer: Anaplerotic pathway

Step by step solution

01

Identify the role of pyruvate carboxylase in metabolic pathways

Pyruvate carboxylase is an enzyme that catalyzes the carboxylation of pyruvate to oxaloacetate. This reaction is an important step in various metabolic pathways, including gluconeogenesis and the citric acid cycle.
02

Recognize the pathway with specific conditions

Under conditions of low energy charge and high acetyl-CoA levels in mitochondria, anaplerotic reactions are crucial to replenish the citric acid cycle intermediates. Pyruvate carboxylase plays a critical role in one of these anaplerotic reactions.
03

Name the pathway

The pathway in which pyruvate carboxylase plays an important role under conditions of low energy charge and high acetyl-CoA levels in mitochondria is called the "Anaplerotic pathway."

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Most popular questions from this chapter

Glycogen contains an \(\alpha-1,6\) -glycosidic bond about once every 10 glucose residues, thereby creating a branch point and a corresponding non reducing end for the removal and addition of glucose molecules. If a glycogen particle contains a total of 50,000 glucose residues, how many nonreducing ends are most likely to be found: \(\sim 25,000\) ends, \(\sim 2,500\) ends, or \(\sim 250\) ends? Explain your answer.

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The \(\Delta G^{\circ \prime}\) of the glycogen phosphorylase reaction is \(+3.1 \mathrm{kJ} / \mathrm{mol},\) whereas the \(\Delta G\) under physiologic conditions is \(-6 \mathrm{kJ} / \mathrm{mol} .\) What is likely to account for this difference of \(\sim 9 \mathrm{kJ} / \mathrm{mol}\) between the \(\Delta G^{\circ \prime}\) and \(\Delta G\) values?

What is the metabolic logic of reciprocal regulation of the glycolytic and gluconeogenic pathways by citrate?

The conversion of pyruvate to phosphoenolpyruvate in the gluconeogenic pathway requires phosphoryl transfer energy in reactions catalyzed by the enzymes pyruvate carboxylase (ATP dependent) and phosphoenolpyruvate carboxykinase (GTP dependent). Why is this pair of reactions counted as a cost of 4 ATP equivalents to convert pyruvate to phosphoenolpyruvate when counting up the number of ATP needed to generate one molecule of glucose?
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