Compare and contrast the action of transcriptional activators in eukaryotes and prokaryotes.

Question: Explain the main differences between transcriptional activators in eukaryotes and prokaryotes. Answer: The main differences between transcriptional activators in eukaryotes and prokaryotes are: 1) the location of enhancer sequences, where in eukaryotes, they can be far from the promoter, while in prokaryotes, they are located closer to the promoter; 2) the chromatin structure, where eukaryotes have a more complex structure that requires remodeling, while prokaryotes lack this complexity; 3) combinatorial control, with eukaryotes often requiring multiple transcriptional activators and cofactors, while prokaryotes generally have a simpler mechanism involving a single activator; and 4) the complexity of activator domains, with eukaryotic activators typically having more domains than their prokaryotic counterparts.