In cancer cells, alteration to epigenetic modifications turns off genes that are normally expressed. Hypothetically, how could you reverse this process to turn these genes back on?

Short Answer

Expert verified

You can develop drugs that open up the chromosome structure by reversing the epigenetic processes (adding histone acetylation marks or removing DNA methylation).

Step by step solution

01

Introduction

DNA can undergo epigenetic alterations, which control whether genes are activated or not. The sequence of the DNA building blocks is not changed by these changes, which are bonded to DNA. DNA methylation is one type of epigenetic modification that results from the addition of a methyl group, sometimes known as a "chemical cap," to a portion of the DNA molecule. This alteration stops some genes from being produced. Histone modification is another illustration.

02

The explanation for the answer

Mammals' normal development and maintenance of tissue-specific gene expression patterns depend heavily on epigenetic processes. Alterations in gene activity and cancerous cellular transformation can result from epigenetic process disruption. One distinguishing feature of cancer is broad changes in the epigenetic environment.

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