If a series of genetic mutations prevented some, but not all, of the complement proteins from binding antibodies or pathogens, would the entire complement system be compromised?

A large number of different plasma proteins, which react with each other to opsonize pathogens and instigate an array of inflammatory reactions, which assist in fighting infection is known as the complement system.

The system is formed of proteases, which possess the tendency to activate themselves by proteolytic cleavage.

In the given case, even when some of the members are mutated they would lose the tendency to combine, thus, the entire complement system would possibly get affected. As the complement involves the combining of activated proteins in a particular alignment, when one or more proteins are absent in the sequence, the subsequent proteins would fail to combine and thus would fail to provoke the complement’s pathogen-destructive effects.