How does MPF allow a cell to pass the G₂phase checkpoint and enter mitosis?(See Figure 12.16)

The maturation promoting factor is otherwise called as mitosis promoting factor. It is a protein complex that initiates the process of mitosis after a regulatory checkpoint.

A cell cycle checkpoint is a scanning within the cellular mechanism to avoid the multiplication of damaged cells. G₂ phase checkpoint is the checkpoint in which the chromosomes and DNA are checked for damage before they enter into mitosis.

The cell has to get into the G₂checkpoint with the help of the mitosis-promoting factor (MPF). MPF gets activated only by combining cyclin with Cdks.

Cyclin is the protein that regulates the cell in the cell cycle process. Cdks is the kinase protein dependent on the cyclin. Therefore, enough accumulation of cyclin indirectly triggers theG₂ phase checkpoint.

After the activation of MPF, it, in turn, activates the other protein resulting in the activation of the mitosis phase, and the cells can enter this phase after the G₂ phase.