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Chapter 15: Q15.3-3CC (page 306)

Gene A, B, and C are located on the same chromosome. Test crosses show that the recombination frequency between A and B is 28% and that between A and C is 12%. Can you determine the linear order of these genes?

Short Answer

Expert verified

There are two possibilities of arranging the genes, such as A-C-B or C-A-B. It is difficult to determine the linear order without the recombination frequency between B and C being predicted.

Step by step solution

01

Definition of gene and chromosome

The portion of DNA that is coding for a particular protein is known as a gene. The chromosomes are the linear structure that is composed of DNA and protein-bound towards each other.

02

Description of recombination frequency

In two genes, the frequency that corresponds to the single chromosome cross is known as recombination frequency. The unit of recombination frequency is the centimorgan. It is denoted by the symbol of θ.

03

Prediction of recombinant frequency in the gene A, B, and C.

The recombination frequency of test crosses between the gene A and B is 28%. The recombination frequency of the other two genes, A and C, is 12%.

The linear order of gene arrangement can take place in two ways, such as A-C-BorC-A-B. It is difficult to predict the exact linear formation formed from these two combinations. It is necessary to know the recombination frequency of another pair, such as B and C.

Hence, the recombination frequency of another pair, such as B and C, is necessary to determine the linear order of the genes.

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Most popular questions from this chapter

For each type of offspring of the test-cross in Figure 15.9, explain the relationship between its phenotype and the alleles contributed by the female parent. (It will be useful to draw out the chromosomes of each fly and follow alleles throughout the cross.)

The goodness of fit is measured by\({\chi ^{^2}}\). This statistic measures the amounts by which the observed values differ from their respective predictions to indicate how closely the two sets of values match. The formula for calculating this value is

\({\chi ^{}} = \sum \frac{{{{\left( {o - e} \right)}^2}}}{e}\)

Where o=observed and e= expected. Calculate the\({\chi ^{^2}}\)value for the data using the table below. Fill out the table, carrying out the operations indicated in the top row. Then add up the entries in the last column to find the\({\chi ^{^2}}\)value.

Testcross Offspring

Expected

(e)

Observed

(o)

Deviation

(o-e)

(o-e)2

(o-e)2/e

(A-B-)

220

(aaB-)

210

(A-bb)

231

(aabb)

239

\({\chi ^2}\) =sum

A white-eyed Drosophila is mated with a red-eyed (wild-type) male, the reciprocal cross of the one shown in Fig 15.4. What phenotypes and genotypes do you predict for the offspring from this cross?

Pseudohypertrophic muscular dystrophy is an inherited disorder that causes gradual deterioration of the muscles. It is seen almost exclusively in boys born to apparently unaffected parents and usually results in death in the early teens. Is this disorder caused by a dominant or a recessive allele? Is its inheritance sex-linked or autosomal? How do you know? Explain why this disorder is almost never seen in girls.

The continuity of life is based on heritable information in the form of DNA. In a short essay (100-150 words), relate the structure and behavior of chromosomes to inheritance in both asexually and sexually reproducing species.
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