Chapter 10: Problem 11
How are the carbon and nitrogen atoms of the sugars, purines, and pyrimidines numbered?
Chapter 10: Problem 11
How are the carbon and nitrogen atoms of the sugars, purines, and pyrimidines numbered?
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Get started for freeConsider the structure of double-stranded DNA. When DNA is placed into distilled water, it denatures; however, by adding \(\mathrm{NaCl}\), the DNA renatures. Why?
Newsdate: March \(1,2030 .\) A unique creature has been discovered during exploration of outer space. Recently, its genetic material has been isolated and analyzed. This material is similar in some ways to DNA in its chemical makeup. It contains in abundance the 4 -carbon sugar erythrose and a molar equivalent of phosphate groups. In addition, it contains six nitrogenous bases: adenine (A), guanine (G), thymine (T), cytosine (C), hypoxanthine (H), and xanthine (X). These bases exist in the following relative proportions: $$\mathrm{A}=\mathrm{T}=\mathrm{H} \text { and } \mathrm{C}=\mathrm{G}=\mathrm{x}$$ X-ray diffraction studies have established a regularity in the molecule and a constant diameter of about 30 A. Together, these data have suggested a model for the structure of this molecule. (a) Propose a general model of this molecule. Describe it briefly. (b) What base-pairing properties must exist for \(\mathrm{H}\) and for \(\mathrm{X}\) in the model? (c) Given the constant diameter of \(30 \AA\), do you think that either (i) both \(\mathrm{H}\) and \(\mathrm{X}\) are purines or both pyrimidines, or (ii) one is a purine and one is a pyrimidine?
Discuss the reasons proteins were generally favored over DNA as the genetic material before \(1940 .\) What was the role of the tetranucleotide hypothesis in this controversy?
One of the most common spontaneous lesions that occurs in DNA under physiological conditions is the hydrolysis of the amino group of cytosine, converting the cytosine to uracil. What would be the effect on DNA structure of a uracil group replacing cytosine?
Present an overview of two classical experiments that demonstrated that DNA is the genetic material. Can RNA be the genetic material? Explain. What observations are consistent with the conclusion that DNA
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