Chapter 14: Problem 30
How does an enzyme function? Why are enzymes essential for living organisms on Earth?
Chapter 14: Problem 30
How does an enzyme function? Why are enzymes essential for living organisms on Earth?
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Get started for freeEarly detection and adherence to a strict dietary regime have prevented much of the mental retardation that used to occur in those afflicted with phenylketonuria (PKU). Affected individuals now often lead normal lives and have families. For various reasons, such individuals adhere less rigorously to their diet as they get older. Predict the effect that mothers with PKU who neglect their diets might have on newborns.
To carry out its role, each transfer RNA requires at least four specific recognition sites that must be inherent in its tertiary structure. What are they?
Knowing the quaternary structure of proteins, specifically their surface properties, provides novel opportunities for enhancing the development of targeted drug therapies. (a) Referring to Figure \(14-16\) and the accompanying discussion, predict the class(es) of amino acids likely to reside on the surface of a protein within a cell. (b) Assuming that Glu, Arg, and Asp exist in a functional site of a receptor molecule on the surface of a cell, provide an amino acid sequence that is likely to be effective in blocking that site. (c) The androgen receptor associated with prostate cancer has recently been targeted using synthetic molecules known generally as peptidomimetics, many of which incorporate D-amino acid stereoisomers rather than the more naturally occurring L-amino acid stereoisomers. Why might \(\mathrm{D}\) -amino acid stereoisomers be especially useful for inhibiting a functional site of the androgen receptor, or any deleterious functional site for that matter? (d) Rational drug design is a relatively recent approach to the design of targeted therapeutic agents. Predict how knowledge of protein structure, especially surface properties, might be used in rational drug design as compared with the more classical "trial-and-error" approach.
Contrast the roles of tRNA and mRNA during translation and list all enzymes that participate in the transcription and translation process.
Define and compare the four levels of protein organization.
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