Chapter 15: Problem 10
Contrast and compare the mutagenic effects of deaminating agents, alkylating agents, and base analogs.
Chapter 15: Problem 10
Contrast and compare the mutagenic effects of deaminating agents, alkylating agents, and base analogs.
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Get started for freeHow would you expect the misincorporation of bases by a DNA polymerase to change if the relative ratios of the dNTPs were \(A=T=G\) but a five-fold excess of \(C ?\)
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DNA damage brought on by a variety of natural and artificial agents elicits a wide variety of cellular responses involving numerous signaling pathways. In addition to the activation of DNA repair mechanisms, there can be activation of pathways leading to apoptosis (programmed cell death) and cell-cycle arrest. Why would apoptosis and cell-cycle arrest often be part of a cellular response to DNA damage?
Describe a tautomeric shift and how it may lead to a mutation.
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