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Chapter 17: Problem 28

AU-rich elements (AREs) are found frequently in the 3'UTR of mRNAs as a means of postranscriptional regulation. Why do you think AREs are found in the mRNAs that encode for proteins of the immune system?

Short Answer

Expert verified
Answer: The primary function of AU-rich elements (AREs) in the 3'UTR of mRNAs encoding immune system proteins is to regulate post-transcriptional gene expression, including mRNA stability, localization, and translation efficiency. They are important in immune response regulation because they allow for fast and flexible adaptation of the immune response to various challenges by ensuring swift production and degradation of proteins needed during the immune response.

Step by step solution

01

Understand AU-rich elements (AREs) in 3'UTR of mRNAs

AU-rich elements (AREs) are short, adenine- and uracil-rich sequences found in the 3' untranslated regions (3'UTR) of mRNAs. Their presence is associated with the post-transcriptional regulation of gene expression, including mRNA stability, localization, and translation efficiency. AREs play a crucial role in determining the half-life of the mRNA, as they can recruit specific RNA-binding proteins that lead to either mRNA stabilization or degradation.
02

Recognize the role of AREs in the immune system

The immune system has to quickly respond to invading pathogens and adapt to various threats. In order to do so, it relies on a tight regulatory mechanism of gene expression to rapidly produce necessary proteins when needed and degrade them when no longer required. AREs play an essential part in this regulation process, enabling immune system cells to adjust protein levels in an efficient and timely manner.
03

Understand the significance of AREs in proteins of the immune system

Many mRNAs encoding proteins of the immune system contain AREs, which allows for swift and flexible control of protein synthesis during immune response. These proteins include cytokines, chemokines, and growth factors, which regulate immune cell survival, proliferation, and differentiation. By controlling the stability and translational efficiency of mRNAs containing AREs, the immune system can quickly adjust its response to the ongoing needs and fine-tune the expression of key regulatory proteins.
04

Explain why AREs are found in mRNAs encoding for immune system proteins

The presence of AREs in the mRNAs encoding for immune system proteins allows for fast and accurate post-transcriptional regulation. It ensures that these proteins are produced and degraded efficiently according to the current needs of the immune response. This rapid modulation of gene expression is crucial for the immune system to effectively recognize, respond, and adapt to diverse pathogens and other threats. In summary, AREs are essential regulatory elements found in the 3'UTR of mRNAs, playing a critical role in post-transcriptional regulation. Their presence in mRNAs encoding for proteins of the immune system ensures a fast and flexible adaptation of the immune response to various challenges.

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