Chapter 17: Problem 5
Describe the organization of the interphase nucleus. Include in your presentation a description of chromosome territories, interchromosomal domains, and transcription factories.
Chapter 17: Problem 5
Describe the organization of the interphase nucleus. Include in your presentation a description of chromosome territories, interchromosomal domains, and transcription factories.
All the tools & learning materials you need for study success - in one app.
Get started for freeExplain the structural features of the Initiator (Inr) elements, BREs, DPEs, and MTEs of focused promoters.
A particular type of anemia in humans, called \(\beta\) -thalassemia, results from a severe reduction or absence of a normal \(\beta\) chain of hemoglobin. A variety of studies have explored the use of 5-azacytidine for the treatment of such patients. How might administration of 5-azacytidine be an effective treatment for \(\beta\) -thalassemia? Would you consider adverse side-effects likely? Why?
What is the mechanism by which the chemical 5-azacytidine enhances gene expression?
Distinguish between the \(c\) is-acting regulatory elements referred to as promoters and enhancers.
A number of experiments have demonstrated that areas of the genome that are relatively inert transcriptionally are resistant to DNase I digestion; however, those areas that are transcriptionally active are DNase I sensitive. Describe how DNase I resistance or sensitivity might indicate transcriptional activity.
What do you think about this solution?
We value your feedback to improve our textbook solutions.