Chapter 19: Problem 19
Describe the difference between an acute transforming virus and a virus that does not cause tumors.
Chapter 19: Problem 19
Describe the difference between an acute transforming virus and a virus that does not cause tumors.
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Get started for freeDescribe the steps by which the \(p 53\) gene responds to DNA damage and/or cellular stress to promote cell-cycle arrest and apoptosis. Given that \(p 53\) is a recessive gene and is not located on the X chromosome, why would people who inherit just one mutant copy of a recessive tumor-suppressor gene be at higher risk of developing cancer than those without the recessive gene?
Radiotherapy (treatment with ionizing radiation) is one of the most effective current cancer treatments. It works by damaging DNA and other cellular components. In which ways could radiotherapy control or cure cancer, and why does radiotherapy often have significant side effects?
Vanderbilt University Medical Center maintains a Web site (http://bioinfo.mc.vanderbilt.edu/TSGene/) that contains descriptions of tumor-suppressor genes, including 637 protein-coding genes and 79 noncoding segments of DNA. How can noncoding segments of DNA function or produce products that function as tumor suppressors?
In this chapter, we focused on cancer as a genetic disease, with an emphasis on the relationship between cancer, the cell cycle, and DNA damage, as well as on the multiple steps that lead to cancer. (a) How do we know that malignant tumors arise from a single cell that contains mutations? (b) How do we know that cancer development requires more than one mutation? (c) How do we know that cancer cells contain defects in DNA repair?
What is the connection between cell-signaling cascades and cancer?
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