Chapter 23: Problem 10
Describe the value of using twins in the study of questions relating to the relative impact of heredity versus environment.
Chapter 23: Problem 10
Describe the value of using twins in the study of questions relating to the relative impact of heredity versus environment.
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Get started for freeHeight in humans depends on the additive action of genes. Assume that this trait is controlled by the four loci \(\mathrm{R}, \mathrm{S}, \mathrm{T}\) and \(\mathrm{U}\) and that environmental effects are negligible. Instead of additive versus nonadditive alleles, assume that additive and partially additive alleles exist. Additive alleles contribute two units, and partially additive alleles contribute one unit to height. (a) Can two individuals of moderate height produce offspring that are much taller or shorter than either parent? If so, how? (b) If an individual with the minimum height specified by these genes marries an individual of intermediate or moderate height, will any of their children be taller than the tall parent? Why or why not?
The mean and variance of plant height of two highly inbred strains \(\left(P_{1} \text { and } P_{2}\right)\) and their progeny \(\left(F_{1} \text { and } F_{2}\right)\) are shown here. $$\begin{array}{ccc}\text { Strain } & \text { Mean (cm) } & \text { Variance } \\\\\mathrm{P}_{1} & 34.2 & 4.2 \\\\\mathrm{P}_{2} & 55.3 & 3.8 \\\\\mathrm{F}_{1} & 44.2 & 5.6 \\\\\mathrm{F}_{2} & 46.3 & 10.3\end{array}$$ Calculate the broad-sense heritability \(\left(H^{2}\right)\) of plant height in this species.
Many traits of economic or medical significance are determined by quantitative trait loci (QTLs) in which many genes, usually scattered throughout the genome, contribute to expression. (a) What general procedures are used to identify such loci? (b) What is meant by the term cosegregate in the context of QTL mapping? Why are markers such as RFLPs, SNPs, and microsatellites often used in QTL mapping?
The following variances were calculated for two traits in a herd of hogs. $$\begin{array}{lccc}\text { Trait } & V_{P} & V_{C} & V_{A} \\\\\text { Back fat } & 30.6 & 12.2 & 8.44 \\\\\text { Body length } & 52.4 & 26.4 & 11.70\end{array}$$ (a) Calculate broad-sense \(\left(H^{2}\right)\) and narrow-sense \(\left(h^{2}\right)\) herita bilities for each trait in this herd. (b) Which of the two traits will respond best to selection by a breeder? Why?
Erma and Harvey were a compatible barnyard pair, but a curious sight. Harvey's tail was only \(6 \mathrm{cm}\) long, while Erma's was \(30 \mathrm{cm} .\) Their \(\mathrm{F}_{1}\) piglet offspring all grew tails that were \(18 \mathrm{cm}\) When inbred, an \(\mathrm{F}_{2}\) generation resulted in many piglets (Erma and Harvey's grandpigs), whose tails ranged in \(4-\mathrm{cm}\) intervals from 6 to \(30 \mathrm{cm}(6,10,14,18,22,26, \text { and } 30) .\) Most had \(18-\mathrm{cm}\) tails, while \(1 / 64\) had \(6-\mathrm{cm}\) tails and \(1 / 64\) had \(30-\mathrm{cm}\) tails. (a) Explain how these tail lengths were inherited by describing the mode of inheritance, indicating how many gene pairs were at work, and designating the genotypes of Harvey, Erma, and their 18 -cm-tail offspring. (b) If one of the \(18-\mathrm{cm} \mathrm{F}_{1}\) pigs is mated with one of the \(6-\mathrm{cm}\) \(\mathrm{F}_{2}\) pigs, what phenotypic ratio will be predicted if many offspring resulted? Diagram the cross.
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