Chapter 25: Problem 13
In a population of 10,000 individuals, where 3600 are \(M M\) 1600 are \(N N,\) and 4800 are \(M N,\) what are the frequencies of the \(M\) alleles and the \(N\) alleles?
Chapter 25: Problem 13
In a population of 10,000 individuals, where 3600 are \(M M\) 1600 are \(N N,\) and 4800 are \(M N,\) what are the frequencies of the \(M\) alleles and the \(N\) alleles?
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Get started for freeIn a population that meets the Hardy-Weinberg equilibrium assumptions, \(81 \%\) of the individuals are homozygous for a recessive allele. What percentage of the individuals would be expected to be heterozygous for this locus in the next generation?
A farmer plants transgenic Bt corn that is genetically modified to produce its own insecticide. Of the corn borer larvae feeding on these \(\mathrm{Bt}\) crop plants, only 10 percent survive unless they have at least one copy of the dominant resistance allele \(B\) that confers resistance to the Bt insecticide. When the farmer first plants Bt corn, the frequency of the \(B\) resistance allele in the corn borer population is \(0.02 .\) What will be the frequency of the resistance allele after one generation of corn borers fed on Bt corn?
Read the Chapter Concepts list on page \(681 .\) All these pertain to the principles of population genetics and the evolution of species. Write a short essay describing the roles of mutation, migration, and selection in bringing about speciation.
A form of dwarfism known as Ellis-van Creveld syndrome was first discovered in the late 1930 s, when Richard Ellis and Simon van Creveld shared a train compartment on the way to a pediatrics meeting. In the course of conversation, they discovered that they each had a patient with this syndrome. They published a description of the syndrome in \(1940 .\) Affected individuals have a short-limbed form of dwarfism and often have defects of the lips and teeth, and polydactyly (extra fingers. The largest pedigree for the condition was reported in an Old Order Amish population in eastern Pennsylvania by Victor McKusick and his colleagues (1964). In that community, about 5 per 1000 births are affected, and in the population of \(8000,\) the observed frequency is 2 per \(1000 .\) All affected individuals have unaffected parents, and all affected cases can trace their ancestry to Samuel King and his wife, who arrived in the area in \(1774 .\) It is known that neither King nor his wife was affected with the disorder. There are no cases of the disorder in other Amish communities, such as those in Ohio or Indiana. (a) From the information provided, derive the most likely mode of inheritance of this disorder. Using the HardyWeinberg law, calculate the frequency of the mutant allele in the population and the frequency of heterozygotes, assuming Hardy-Weinberg conditions. (b) What is the most likely explanation for the high frequency of the disorder in the Pennsylvania Amish community and its absence in other Amish communities?
Some critics have warned that the use of gene therapy to correct genetic disorders will affect the course of human evolution. Evaluate this criticism in light of what you know about population genetics and evolution, distinguishing between somatic gene therapy and germ-line gene therapy.
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