Chapter 5: Problem 20
Are mitotic recombinations and sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
Chapter 5: Problem 20
Are mitotic recombinations and sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
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Get started for freeAnother cross in Drosophila involved the recessive, X-linked genes yellow \((y),\) white \((w),\) and \(c u t(c t) .\) A yellow-bodied, white-eyed female with normal wings was crossed to a male whose eyes and body were normal but whose wings were cut. The \(\mathrm{F}_{1}\) females were wild type for all three traits, while the \(\mathrm{F}_{1}\) males expressed the yellow-body and white- eye traits. The cross was carried to an \(\mathrm{F}_{2}\) progeny, and only male offspring were tallied. On the basis of the data shown here, a genetic map was constructed. (a) Diagram the genotypes of the \(\mathrm{F}_{1}\) parents. (b) Construct a map, assuming that white is at locus 1.5 on the X chromosome. (c) Were any double-crossover offspring expected? (d) Could the \(\mathrm{F}_{2}\) female offspring be used to construct the map? Why or why not?
In Drosophila, a cross was made between females-all expressing the three \(X\) -linked recessive traits scute bristles \((s c),\) sable body \((s),\) and vermilion eyes \((v)-\) and wild-type males. In the \(\mathrm{F}_{1},\) all females were wild type, while all males expressed all three mutant traits. The cross was carried to the \(\mathrm{F}_{2}\) generation, and 1000 offspring were counted, with the results shown in the following table. No determination of sex was made in the data. (a) Using proper nomenclature, determine the genotypes of the \(P_{1}\) and \(F_{1}\) parents. (b) Determine the sequence of the three genes and the map distances between them. (c) Are there more or fewer double crossovers than expected? (d) Calculate the coefficient of coincidence. Does it represent positive or negative interference?
In Drosophila, a female fly is heterozygous for three mutations, Bar eyes \((B),\) miniature wings \((m),\) and ebony body \((e)\) Note that Bar is a dominant mutation. The fly is crossed to a male with normal eyes, miniature wings, and ebony body. The results of the cross are as follows. Interpret the results of this cross. If you conclude that linkage is involved between any of the genes, determine the map distance(s) between them.
A backcross was set up between two homozygous laboratory mouse strains \(A\) and \(B\), with the \(F_{1}\) backcrossed to \(B\). The \(F_{2}\) were typed using \(\operatorname{SNPs} x\) and \(y,\) which varied between strains \(A\) and \(B\left(x^{A}, x^{B}, y^{A}, y^{B}\right) .\) Out of 100 mice, 38 were \(x^{A} y^{A}, 40\) were \(x^{B} y^{B}, 11\) were \(x^{A} y^{B},\) and 11 were \(x^{B} y^{A} .\) What is the genetic distance between SNPs \(x\) and \(y ?\)
The genes dumpy\((d p),\) clot \((c l),\) and apterous \((a p)\) are linked on chromosome II of Drosophila. In a series of two-point mapping crosses, the following genetic distances were determined. What is the sequence of the three genes?
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