Recent reconstructions of evolutionary history are often dependent on
assigning divergence in terms of changes in amino acid or nucleotide
sequences. For example, a comparison of cytochrome
c shows 10 amino acid differences between humans and dogs, 24 differences
between humans and moths, and 38 differences
between humans and yeast. Such data provide no information as to the absolute
times of divergence for humans, dogs, moths, and yeast. How might one
calibrate the molecular clock to an absolute time clock? What problems might
one encounter in such a
calibration?