Explain why the one-gene:one-enzyme hypothesis is no longer considered to be totally accurate.

Answer: The current understanding of gene-protein relationships is more complex than the original one-gene:one-enzyme hypothesis. While the original hypothesis stated that each gene was responsible for producing a single enzyme, modern molecular biology has developed the one-gene:one-polypeptide concept, recognizing that a gene can produce a polypeptide chain that may or may not have enzymatic activity. Additionally, genetic information can be differentially spliced and regulated to produce multiple protein isoforms, increasing the proteome's complexity and the number of proteins that a single gene could potentially produce. This updated version acknowledges the complexities and exceptions of gene-protein relationships better than the original hypothesis.