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Chapter 16: Problem 24

How is it possible that a given mRNA in a cell is found throughout the cytoplasm but the protein that it encodes is only found in a few specific regions?

Short Answer

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Short Answer: The presence of the specific mRNA throughout the cytoplasm and its corresponding protein only in specific regions can be attributed to a combination of regulation of protein synthesis and targeted protein localization. The protein synthesis can be regulated through mechanisms such as RNA-binding proteins or sequestration of mRNA, and the localized protein can be determined by signal sequences and other protein interactions within the cell.

Step by step solution

01

Understanding mRNA distribution in the cytoplasm

mRNA is transcribed from DNA in the nucleus and then exported to the cytoplasm, where it serves as a template for protein synthesis. In the cytoplasm, the mRNA can be distributed fairly evenly due to the movement of molecules and be present throughout the cell.
02

Translation of mRNA into protein

In the cytoplasm, the mRNA molecule is translated into a protein by ribosomes. This process involves reading the genetic code in the mRNA and assembling the corresponding amino acids into a polypeptide chain, which then folds into the final protein structure.
03

Regulation of protein synthesis

It is possible that the synthesis of the protein coded by the mRNA is regulated in a way that only allows its production in specific regions of the cell. This can be achieved by various mechanisms, such as the presence of specific RNA-binding proteins that inhibit translation or the sequestration of the mRNA into specific subcellular compartments.
04

Protein localization

Once the protein has been synthesized, it can be localized to specific regions within the cell. This can be determined by the presence of signal sequences within the protein, which are recognized by cellular machinery that transports the protein to its desired location. Additionally, the protein can also be anchored to specific cellular structures or interact with other proteins that help maintain its position in specific regions.
05

Conclusion

The presence of mRNA throughout the cytoplasm, but its corresponding protein only in specific regions, can be attributed to a combination of regulation of protein synthesis and targeted protein localization. The protein synthesis can be regulated through various mechanisms, and the localized protein can be determined by signal sequences and other protein interactions within the cell.

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Most popular questions from this chapter

Review the Chapter Concepts list on p. \(302 .\) The third concept describes how transcription initiation requires the assembly of transcription regulatory proteins on DNA sites known as promoters, enhancers, and silencers. Write a short essay describing which types of trans-acting proteins bind to which type of cis-regulatory element, and how these interactions influence transcription initiation.

Explain how the use of alternative promoters and alternative polyadenylation signals produces mRNAs with different \(5^{\prime}-\) and \(3^{\prime}\) -ends.

The proteasome is a multi-subunit machine that unfolds and degrades proteins. How is its activity regulated such that it only degrades certain proteins?

Describe the manner in which activators and repressors influence the rate of transcription initiation. How might chromatin structure be involved in such regulation?

In principle, RNAi may be used to fight viral infection. How might this work?
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