Chapter 19: Problem 17
What are the most significant environmental agents that contribute to human cancers?
Chapter 19: Problem 17
What are the most significant environmental agents that contribute to human cancers?
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Get started for freeThose who inherit a mutant allele of the \(R B 1\) tumor-suppressor gene are at risk for developing a bone cancer called osteosarcoma. You suspect that in these cases, osteosarcoma requires a mutation in the second \(R B 1\) allele, and you have cultured some osteosarcoma cells and obtained a cDNA clone of a normal human \(R B 1\) gene. A colleague sends you a research paper revealing that a strain of cancer-prone mice develops malignant tumors when injected with osteosarcoma cells, and you obtain these mice. Using these three resources, indicate which experiments you would perform to determine the following: (a) whether osteosarcoma cells carry two \(R B 1\) mutations, (b) whether osteosarcoma cells produce any pRB protein, (c) if the addition of a normal \(R B 1\) gene will change the cancercausing potential of osteosarcoma cells.
Describe kinases and cyclins. How do they interact to cause cells to move through the cell cycle?
What is apoptosis, and under what circumstances do cells undergo this process?
Define tumor-suppressor genes.Why is a mutation in a single copy of a tumor- suppressor gene expected to behave as a recessive gene?
Of the two classes of genes associated with cancer, tumor-suppressor genes and oncogenes, mutations in which group can be considered gain-of-function mutations? In which group are the loss-of-function mutations? Explain.
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