Chapter 21: Problem 25
List the barriers that prevent interbreeding, and give an example of each.
Chapter 21: Problem 25
List the barriers that prevent interbreeding, and give an example of each.
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Get started for freeOne of the first Mendelian traits identified in humans was a dominant condition known as brachydactyly. This gene causes an abnormal shortening of the fingers or toes (or both). At the time, some researchers thought that the dominant trait would spread until 75 percent of the population would be affected (because the phenotypic ratio of dominant to recessive is 3: 1 ). Show that the reasoning was incorrect.
Assume that a recessive autosomal disorder occurs in 1 of 10,000 individuals (0.0001) in the general population and that in this population about 2 percent (0.02) of the individuals are carriers for the disorder. Estimate the probability of this disorder occurring in the offspring of a marriage between first cousins. Compare this probability to the population at large.
A form of dwarfism known as Ellis-van Creveld syndrome was first discovered in the late 1930 s, when Richard Ellis and simon van Creveld shared a train compartment on the way to a pediatrics meeting. In the course of conversation, they discovered that they each had a patient with this syndrome. They published a description of the syndrome in \(1940 .\) Individuals with this syndrome have a short-limbed form of dwarfism and often have defects of the lips and teeth, and polydactyly (extra fingers). The largest pedigree for the condition was reported in an Old Order Amish population in eastern Pennsylvania by Victor McKusick and his colleagues \((1964) .\) In that population of \(8000,\) the observed frequency is 2 per \(1000 .\) In all cases, parents of children with the syndrome were unaffected, and all cases can be traced to Samuel King and his wife, who arrived in the area in \(1774 .\) It is known that neither King nor his wife was affected with the disorder. There are no cases of the disorder in other Amish communities, such as those in Ohio or Indiana. (a) From the information provided, derive the most likely mode of inheritance of this disorder. Using the Hardy-Weinberg law, calculate the frequency of the mutant allele in the population and the frequency of heterozygotes, assuming Hardy-Weinberg conditions. (b) What is the most likely explanation for the high frequency of the disorder in the Pennsylvania Amish community and its absence in other Amish communities?
Price et al. \([(1999) . \text { J. Bacteriol. } 181: 2358-2362]\) conducted a genetic study of the toxin transport protein (PA) of Bacillus anthracis, the bacterium that causes anthrax in humans. Within the 2294 -nucleotide gene in 26 strains they identified five point mutations- two missense and three synonyms-among different isolates. Necropsy samples from an anthrax outbreak in 1979 revealed a novel missense mutation and five unique nucleotide changes among ten victims. The authors concluded that these data indicate little or no horizontal transfer between different B. anthracis strains. (a) Which types of nucleotide changes (missense or synonyms) cause amino acid changes? (b) What is meant by "horizontal transfer"? (c) On what basis did the authors conclude that evidence of horizontal transfer is absent from their data?
HOW DO WE KNOW? Population geneticists study changes in the nature and amount of genetic variation in populations, the distribution of different genotypes, and how forces such as selection and drift act on genetic variation to bring about evolutionary change in populations and the formation of new species. From the explanation given in the chapter, what answers would you propose to the following fundamental questions? (a) How do we know how much genetic variation is in a population? (b) How do geneticists detect the presence of genetic variation as different alleles in a population? (c) How do we know whether the genetic structure of a population is static or dynamic? (d) How do we know when populations have diverged to the point that they form two different species? (e) How do we know the age of the last common ancestor shared by two species?
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