In mice, the Sry gene (see Section 5.2) is located on the Y chromosome very close to one of the pseudoautosomal regions that pairs with the X chromosome during male meiosis. Given this information, propose a model to explain the generation of unusual males who have two X chromosomes (with an Sry-containing piece of the Y chromosome attached to one X chromosome).

Short Answer

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Question: Explain the generation of unusual males with two X chromosomes, where one of them has an Sry-containing piece of the Y chromosome attached. Answer: The generation of unusual males with two X chromosomes occurs due to a rare recombination event during meiosis in the parent. In this event, the Sry gene, which is usually located on the Y chromosome, gets transferred to the X chromosome. As a result, individuals with an X chromosome from the mother and an X' chromosome (X chromosome with Sry gene) from the father would be genotypically XX, but still possess the Sry gene, causing them to develop male characteristics. This leads to unusual males with two X chromosomes, where one of the X chromosomes has an Sry-containing piece of the Y chromosome attached.

Step by step solution

01

Understand Meiosis and Sry Gene Location

Meiosis is the process in which parent diploid cells divide to produce haploid cells, like sperm and eggs, with half the number of chromosomes. During the first phase of meiosis, homologous chromosomes (chromosomes that have the same sequence of genes and structure) pair up and exchange genetic material through recombination. The Sry gene is usually located on the Y chromosome, however, the unusual males will have it on the X chromosome. Since the Sry gene lies close to one of the pseudoautosomal regions where homologous recombination occurs, this detail is essential in our explanation.
02

Propose a Model of Recombination Involving Sry Gene Transfer

We propose a model that involves a rare recombination event between the X and Y chromosomes at the Sry gene region. During meiosis in the male's parent, a crossing-over event could have occurred between the X and Y chromosomes. This event involves an exchange of genetic material between chromosomes and in this case, the transfer of the Sry-containing piece between the X and the Y chromosome.
03

Analyze the Result of Recombination

After the recombination event, the outcome would be two types of chromosomes: an X chromosome with the Sry gene (referred to as X') and a Y chromosome without the Sry gene (referred to as Y'). The sperm cells carrying these chromosomes would generate unusual offspring when they fertilize the eggs.
04

Explain the Generation of Unusual Males

The unusual male offspring would inherit an X chromosome from the mother and an X' chromosome (X chromosome containing the Sry gene) from the father. These individuals would be genotypically XX but still possess the Sry gene, causing them to develop male characteristics. Thus, these males would have two X chromosomes, with one of the X chromosomes having an Sry-containing piece of the Y chromosome attached.

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