Two different female Drosophila were isolated, each heterozygousfor the autosomally linked genes black body (b), dachs tarsus (d), and curved wings (c). These genes are in the order \(d-b-c\), with \(b\) closer to \(d\) than to $c .$ Shown in the following table is the genotypic arrangement for each female, along with the various gametes formed by both. Identify which categories are noncrossovers (NCO), single crossovers (SCO), and double crossovers (DCO) in each case. Then, indicate the relative frequency with which each will be produced.

Short Answer

Expert verified
Answer: The relative frequencies of NCO, SCO, and DCO for Drosophila are approximately 50%, 50%, and 12.5%, respectively. Note that the actual relative frequencies may vary depending on the distance between genes and other factors involved in crossover events.

Step by step solution

01

Genotypic arrangement for each female

We are given the genotypic arrangement for each female Drosophila and the various gametes formed. Let's represent these arrangements using gene symbols for easier analysis. Female 1: --------- Normal arrangement (N): \(D B C\) Mutant arrangement (M): \(d b c\) Female 2: --------- Normal arrangement (N): \(D B C\) Mutant arrangement (M): \(d b c\)
02

Determine NCO, SCO, and DCO

To identify the noncrossovers (NCO), single crossovers (SCO), and double crossovers (DCO), we will look for the combinations of genes formed by the gametes for each female. Female 1: --------- NCO: \(DB C\) and \(d b c\) SCO: \(D b C\) and \(d B c\) DCO: \(D B c\) and \(d b C\) Here, NCO represents no exchanges of genes, SCO represents one exchange between \(d\) and \(b\), and DCO represents exchanges between both \(d,b\) and \(b,c\). Female 2: --------- NCO: \(DB C\) and \(d b c\) SCO: \(D b C\) and \(d B c\) DCO: \(D B c\) and \(d b C\) The same combinations are formed for both females as they have the same genotypic arrangements.
03

Calculate relative frequency

To calculate the relative frequency of NCO, SCO, and DCO, we will compare their occurrence rates to the total number of gametes possible for each female. Given the order of genes as \(d-b-c\), we know that \(b\) is closer to \(d\) than to \(c\). This means that the recombination frequency between \(d\) and \(b\) is smaller than the frequency between \(b\) and \(c\). Combination Rates: ------------------- NCO: \(DB C\) and \(d b c\) (both recombinations not occurring) SCO: \(D b C\) and \(d B c\) (recombination between \(d\) and \(b\)) DCO: \(D B c\) and \(d b C\) (both recombinations occurring) For each combination, the relative frequency can be calculated by dividing the number of occurrences of each gene combination by the total number of possible gametes (assuming all are equally likely). NCO Frequency: \(\frac{1}{4}+\frac{1}{4}=\frac{1}{2}=50\%\) SCO Frequency: \(\frac{1}{4}+\frac{1}{4}=\frac{1}{2}=50\%\) DCO Frequency: \(\frac{1}{16}+\frac{1}{16}=\frac{1}{8}=12.5\%\) (Note: This is an assumption since the actual frequencies depend on the distance between the different genes). In conclusion, the relative frequencies of NCO, SCO, and DCO are approximately 50%, 50%, and 12.5%, respectively. It is important to note that the actual relative frequencies will be affected by various factors, including the distance between genes and the specific processes involved in crossover events.

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Most popular questions from this chapter

Review the Chapter Concepts list on p. \(121 .\) Most of these center on the process of crossing over between linked genes. Write a short essay that discusses how crossing over can be detected and how the resultant data provide the basis of chromosome mapping.

In this chapter, we focused on linkage, chromosomal mapping, and many associated phenomena. In the process, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions? (a) How was it established experimentally that the frequency of recombination (crossing over) between two genes is related to the distance between them along the chromosome? (b) How do we know that specific genes are linked on a single chromosome, in contrast to being located on separate chromosomes? (c) How do we know that crossing over results from a physical exchange between chromatids? (d) How do we know that sister chromatids undergo recombination during mitosis?

A female of genotype \\[ \frac{a}{+++} \\] produces 100 meiotic tetrads. Of these, 68 show no crossover events. Of the remaining 32,20 show a crossover between \(a\) and \(b\), 10 show a crossover between \(b\) and \(c,\) and 2 show a double crossover between \(a\) and \(b\) and between \(b\) and \(c .\) Of the 400 gametes produced, how many of each of the eight different genotypes will be produced? Assuming the order \(a-b-c\) and the allele arrangement shown above, what is the map distance between these loci?

In Drosophila, a cross was made between females expressing the three X-linked recessive traits, scute bristles \((s c),\) sable body \((s)\) and vermilion eyes ( \(v\) ), and wild-type males. All females were wild type in the \(F_{1},\) while all males expressed all three mutant traits. The cross was carried to the \(\mathrm{F}_{2}\) generation and 1000 offspring were counted, with the results shown in the following table. No determination of sex was made in the \(\mathrm{F}_{2}\) data. (a) Using proper nomenclature, determine the genotypes of the \(P_{1}\) and \(F_{1}\) parents. (b) Determine the sequence of the three genes and the map distance between them. (c) Are there more or fewer double crossovers than expected? (d) Calculate the coefficient of coincidence; does this represent positive or negative interference?

The genes dumpy wings \((d p),\) clot eyes \((c l),\) and apterous wings \((a p)\) are linked on chromosome II of Drosophila. In a series of twopoint mapping crosses, the genetic distances shown below were determined. What is the sequence of the three genes?

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