Chapter 7: Problem 25
Are sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
Chapter 7: Problem 25
Are sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?
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Get started for freeA female of genotype \\[ \frac{a}{+++} \\] produces 100 meiotic tetrads. Of these, 68 show no crossover events. Of the remaining 32,20 show a crossover between \(a\) and \(b\), 10 show a crossover between \(b\) and \(c,\) and 2 show a double crossover between \(a\) and \(b\) and between \(b\) and \(c .\) Of the 400 gametes produced, how many of each of the eight different genotypes will be produced? Assuming the order \(a-b-c\) and the allele arrangement shown above, what is the map distance between these loci?
In Drosophila, Dichaete ( \(D\) ) is a mutation on chromosome III with a dominant effect on wing shape. It is lethal when homozygous. The genes \(e\)bony body \((e)\) and pink eye (p) are recessive mutations on chromosome III. Flies from a Dichaete stock were crossed to homozygous ebony, pink flies, and the \(\mathrm{F}_{1}\) progeny with a Dichaete phenotype were backcrossed to the ebony, pink homozygotes. (a) Using the results of this backcross shown in the following table, diagram the cross, showing the genotypes of the parents and offspring of both crosses. (b) What is the sequence and interlocus distance between these three genes?
Why are double-crossover events expected less frequently than single-crossover events?
In Drosophila, the two mutations Stubble bristles (Sb) and curled wings ( $c u$ ) are linked on chromosome III. Sb is a dominant gene that is lethal in a homozygous state, and \(c u\) is a recessive gene. If a female of the genotype \\[ \frac{S b}{+} \\] is to be mated to detect recombinants among her offspring, what male genotype would you choose as her mate?
In Creighton and McClintock's experiment demonstrating that crossing over involves physical exchange between chromosomes (see Section 7.6 ), explain the importance of the cytological markers (the translocated segment and the chromosome knob) in the experimental rationale.
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