Chapter 7: Problem 4
Why does more crossing over occur between two distantly linked genes than between two genes that are very close together on the same chromosome?
Chapter 7: Problem 4
Why does more crossing over occur between two distantly linked genes than between two genes that are very close together on the same chromosome?
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Get started for freeWhat three essential criteria must be met in order to execute a successful mapping cross?
In Drosophila, the two mutations Stubble bristles (Sb) and curled wings ( $c u$ ) are linked on chromosome III. Sb is a dominant gene that is lethal in a homozygous state, and \(c u\) is a recessive gene. If a female of the genotype \\[ \frac{S b}{+} \\] is to be mated to detect recombinants among her offspring, what male genotype would you choose as her mate?
Why are double-crossover events expected less frequently than single-crossover events?
In this chapter, we focused on linkage, chromosomal mapping, and many associated phenomena. In the process, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter, what answers would you propose to the following fundamental questions? (a) How was it established experimentally that the frequency of recombination (crossing over) between two genes is related to the distance between them along the chromosome? (b) How do we know that specific genes are linked on a single chromosome, in contrast to being located on separate chromosomes? (c) How do we know that crossing over results from a physical exchange between chromatids? (d) How do we know that sister chromatids undergo recombination during mitosis?
The genes dumpy wings \((d p),\) clot eyes \((c l),\) and apterous wings \((a p)\) are linked on chromosome II of Drosophila. In a series of twopoint mapping crosses, the genetic distances shown below were determined. What is the sequence of the three genes?
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