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Chapter 7: Problem 8

What three essential criteria must be met in order to execute a successful mapping cross?

Short Answer

Expert verified
Answer: The three essential criteria for a successful mapping cross are linkage, recombination, and large sample size.

Step by step solution

01

1. Linkage

The genes involved in the mapping cross should be linked, meaning they are located on the same chromosome or closely positioned together. This is crucial for determining genetic distances between those genes and observing the effects of recombination.
02

2. Recombination

The purpose of the mapping cross is to observe the frequency of recombination among offspring, which reflects the relative distances between the genes. To achieve this, the mapping cross must be set up in such a way that genetic material is exchanged between homologous chromosomes during meiosis, leading to the production of recombinant gametes. Parents involved in the cross should have different alleles for the genes being studied, allowing for clear observation of recombination events in the offspring.
03

3. Large Sample Size

In order to obtain accurate and reliable results, a large number of offspring must be produced and analyzed for their gene combinations. A larger sample size minimizes the effects of random chance and provides a more accurate representation of recombination frequencies and genetic distances. It also ensures that rare recombination events are adequately represented in the results.

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Most popular questions from this chapter

In Creighton and McClintock's experiment demonstrating that crossing over involves physical exchange between chromosomes (see Section 7.6 ), explain the importance of the cytological markers (the translocated segment and the chromosome knob) in the experimental rationale.

DNA markers have greatly enhanced the mapping of genes in humans. What are DNA markers, and what advantage do they confer?

Why does more crossing over occur between two distantly linked genes than between two genes that are very close together on the same chromosome?

Are sister chromatid exchanges effective in producing genetic variability in an individual? in the offspring of individuals?

In Drosophila, the two mutations Stubble bristles (Sb) and curled wings ( $c u$ ) are linked on chromosome III. Sb is a dominant gene that is lethal in a homozygous state, and \(c u\) is a recessive gene. If a female of the genotype \\[ \frac{S b}{+} \\] is to be mated to detect recombinants among her offspring, what male genotype would you choose as her mate?
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