Mention the causative agents of DNA lesions in the human body that can lead to cancer.

Answer: The causative agents of DNA lesions that can potentially lead to cancer include: 1. Ultraviolet (UV) radiation, which creates DNA lesions called pyrimidine dimers, causing mutations if not accurately repaired; 2. Ionizing radiation, such as X-rays and gamma rays, which cause single and double-strand breaks, as well as base modifications in DNA; 3. Chemical carcinogens like tobacco smoke and aflatoxins, which can cause various types of DNA damage and lead to cancer development; 4. Viruses, such as HPV and HBV, which cause DNA damage by integrating their viral DNA into the host genome, disrupting normal cellular functions; 5. Spontaneous mutations, which occur naturally or as a result of errors in DNA repair mechanisms, causing DNA damage that may accumulate over time and potentially lead to cancer.