Chapter 16: Problem 24
While all cancer cells are proliferative, only some become malignant. Explain this statement.
Chapter 16: Problem 24
While all cancer cells are proliferative, only some become malignant. Explain this statement.
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Get started for freeIf a cell suffers damage to its DNA while in S phase, how can this damage be repaired before the cell enters mitosis?
A study by Bose and colleagues \((1998 . \text { Blood } 92: 3362-3367)\) and a previous study by Biernaux and others (1996. Bone Marrow Transplant 17: (Suppl. 3) S45-S47) showed that BCR-ABL fusion gene transcripts can be detected in 25 to 30 percent of healthy adults who do not develop chronic myelogenous leukemia (CML). Explain how these individuals can carry a fusion gene that is transcriptionally active and yet do not develop CML.
Distinguish between oncogenes and proto-oncogenes. In what ways can proto- oncogenes be converted to oncogenes?
A genetic variant of the retinoblastoma protein, called PSM-RB (phosphorylation site mutated \(\mathrm{RB}\) ), is not able to be phosphorylated by the action of CDK4/cyclin D1 complex. Explain why PSM-RB is said to have a constitutive growth-suppressing action on the cell cycle.
Part of the Ras protein is associated with the plasma membrane, and part extends into the cytoplasm. How does the Ras protein transmit a signal from outside the cell into the cytoplasm? What happens in cases where the ras gene is mutated?
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