An unapproved form of gene therapy, known as enhancement gene therapy, can create considerable ethical dilemmas. Why?

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Answer: The main ethical dilemmas associated with enhancement gene therapy include concerns about safety, unequal access to treatment, individual autonomy and consent, potential for abuse and misuse, and the impact on human identity and dignity. These dilemmas arise because enhancement gene therapy, which aims to improve non-medical characteristics or abilities, is often unapproved and not thoroughly researched or regulated, leading to potential negative consequences on individual and societal levels.

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01

Introduction to enhancement gene therapy

Enhancement gene therapy refers to the use of genetic modification techniques to improve or augment certain characteristics or abilities in an individual that are not related to treating or curing diseases or medical conditions. This form of therapy is often unapproved and not authorized for medical use due to many ethical concerns.
02

Ethical concerns about safety

One of the main ethical issues surrounding enhancement gene therapy is its safety. As it is an unapproved form of therapy, thorough research and testing may not be conducted, potentially leading to negative side effects or health problems for individuals who undergo the treatment. Without rigorous testing and oversight, there is a risk of harm to patients, which raises ethical concerns about the potential consequences of such therapies.
03

Unequal access to treatment

Another ethical concern regarding enhancement gene therapy is the potential for unequal access to these treatments. Since these therapies may be expensive and not covered by health insurance, only a small portion of the population may be able to afford them. This could lead to an unfair distribution of enhanced abilities, advantages, and opportunities, creating social inequality and further widening the gap between the rich and the poor.
04

Ethical concerns about individual autonomy and consent

A critical ethical issue concerning enhancement gene therapy is the potential for infringement on individual autonomy and consent. These treatments often involve irreversible changes to an individual's genetic makeup. Parents may decide to undergo these procedures for their children without consent or input from the child, raising ethical questions about the right to control one's own body and life.
05

Potential for abuse and misuse

There is also an ethical concern about the potential for abuse and misuse of enhancement gene therapy. Some individuals or organizations may be tempted to use these therapies for nefarious purposes or to unfairly compete against others in areas such as sports, academics, or employment. This raises moral questions about the possible consequences of gene enhancement on an individual and societal level.
06

Impact on human identity and dignity

Lastly, enhancement gene therapy can fuel ethical debates about the impact on human identity and dignity. The idea of "designer babies," where parents could potentially select desired traits and abilities for their children, challenges common beliefs about human nature and raises questions about the ethical implications of creating "enhanced" humans. In conclusion, enhancement gene therapy presents various ethical dilemmas due to concerns about safety, unequal access, individual autonomy and consent, the potential for abuse, and the impact on human identity and dignity. Without proper regulations and careful consideration of the ethical implications, this form of therapy could lead to negative consequences on both individual and societal levels.

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Following the tragic shooting of 20 children at a school in Newtown, Connecticut, in 2012 , Connecticut's state medical examiner requested a full genetic analysis of the killer's genome. What do you think investigators might be looking for? What might they expect to find? Might this analysis lead to oversimplified analysis of the cause of the tragedy?

Dominant mutations can be categorized according to whether they increase or decrease the overall activity of a gene or gene product. Although a loss-of- function mutation (a mutation that inactivates the gene product) is usually recessive, for some genes, one dose of the normal gene product, encoded by the normal allele, is not sufficient to produce a normal phenotype. In this case, a loss-of-function mutation in the gene will be dominant, and the gene is said to be haploinsufficient. A second category of dominant mutation is the gain-of- function mutation, which results in a new activity or increased activity or expression of a gene or gene product. The gene therapy technique currently used in clinical trials involves the "addition" to somatic cells of a normal copy of a gene. In other words, a normal copy of the gene is inserted into the genome of the mutant somatic cell, but the mutated copy of the gene is not removed or replaced. Will this strategy work for either of the two aforementioned types of dominant mutations?

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