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Chapter 13: Q30P (page 441)

How does pertussis toxin inhibit phospholipase C?

Short Answer

Expert verified

Pertussis toxin protects against G text protein and prevents GDT from being exchanged for GTP, inhibiting phospholipase C.

Step by step solution

01

Explanation of Concept

The bacterium Bordetella pertussis produces pertussis toxin, a protein-based AB5-type exotoxin that causes whooping cough.The colonization of the respiratory tract and the formation of infection are both aided by PT

02

Preventing it from Inhibiting

Pertussis toxin inhibits phospholipaseCthrough a particular Cys residue ofGiα,preventing it from exchanging GDP for GTP and hence preventing it from inhibiting adenylate cyclase.

Pertussis toxin prevents diffusion of GTP from G proteins, which activates phospholipaseC.

Therefore, Pertussis toxin protects against G text protein and prevents GDT from being exchanged for GTP, inhibiting phospholipase C.

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