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Chapter 17: Q13. (page 586)

What is the ΔG°′ value for the portion of the citric acid cycle that converts malate and acetyl-CoA to citrate?

Short Answer

Expert verified

The total value ofΔGo'=-1.8 kJ mol-1.

Step by step solution

01

Conversion of malate to citrate

Citrate is formed from malate by malate dehydrogenase and citrate synthase reactions.The conversion of malate→citratereactions and their values are as follows:

Malate+NAD+→oxaloacetate+NADH+H+;△G°'1=+29.7kJmole-1

(Malate dehydrogenase reaction)

Acetyl-CoA+oxaloacetate→citrate;△G°'2=-31.5kJmol-1 (Citrate synthase reaction)

02

Total △G°'is the sum of △G°'values of malate dehydrogenase and citrate synthase reaction

Total △G°'for the conversion of malate to citrate is computed by adding the preceding values of △G°'1and△G°'2by the following formula:

Total

role="math" localid="1648637329656" △G°'=△G°'1+△G°'2=+29.7kJmol-1+(-31.5kJmol-1)=-1.8kJmol-1

Therefore, the value of△G°' is-1.8kJmol-1 .

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Most popular questions from this chapter

How does the cell replenish oxaloacetate, α-ketoglutarate, and succinyl-CoA?

Question: The action of malic enzyme opposes the action of pyruvate carboxylase. (a) Diagram the substrate cycle formed by these enzymes plus a third enzyme. (b) Write the net equation for converting malate to pyruvate and back to malate. What does this accomplish for the cell?

Question: Although animals cannot synthesize glucose from acetyl-CoA, if a rat is fed 14C-labeled acetate, some of the label appears in glycogen extracted from its muscles. Explain.

What is the ratio of [isocitrate] to [citrate] under cellular conditions at 37°C?

Does the pyruvate-formatelyase reaction described in Problem 7 lead to the production of ATP, as pyruvate processing to acetyl-CoA does?
See all solutions

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