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Chapter 17: Q16P (page 586)

What is the ratio of [isocitrate] to [citrate] under cellular conditions at 37°C?

Short Answer

Expert verified

Answer

The ratio of isocitrate to citrate at cellular level at the given temperature is found to be 0.14.

Step by step solution

01

Conversion of citrate to isocitrate

Aconitase is an enzyme that catalyzes the citrate to isocitrate conversion.

The reaction can be summarized as shown below:

The standard free energy change for aconitase obtained from the table of citric acid cycle reactions is found to be $Δ G^{o'} = 5 {kJ mol}^{- 1}$ .

02

Ratio of fumarate to succinate calculation

The ratio of isocitrate to citrate is calculated using the following equation:

$Δ G = Δ G^{0} + R T l n K$

Substituting the values in the equation,

$0 = 5000 J m o l^{- 1} + 8.314 J K^{- 1} m o l^{- 1} \times 310 K \times \ln (\frac{c (i s o c i t r a t e)}{c (c i t r a t e)}) - \ln (\frac{c (i s o c i t r a t e)}{c (c i t r a t e)}) = \frac{5000 J / m o l}{2577.34 J / m o l}$

Taking ln to the right-hand side,

$(\frac{c (i s o c i t r a t e)}{c (c i t r a t e)}) = e^{- 1.94} = 0.14$

The ratio of isocitrate to citrate is 0.14.

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Most popular questions from this chapter

The ${CO}_{2}$ produced in one round of the citric acid cycle does not originate in the acetyl carbons that entered that round. If acetyl-CoA is labeled with ${}^{14}C$ at its carbonyl carbon, how many rounds of the cycle are required before ${}^{14}{CO}_{2}$ is released?

Describe the five reactions of the pyruvate dehydrogenase multienzyme complex.

Which citric acid cycle intermediates can be directly used in gluconeogenesis? Which can be used for fatty acid synthesis? Which can be directly converted to amino acids?

Which steps of the citric acid cycle regulate flux through the cycle?

If acetyl-CoA is labeled with ${}^{14}C$ at its methyl group, how many rounds of the cycle are required before ${}^{14}C O_{2}$ is released?

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