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Chapter 17: Q4P (page 586)

Explain why metabolic acidosis (Box 2-2) may result from the accumulation of some citric acid cycle intermediates.

Short Answer

Expert verified

These substances are acids that, if collected, can cause acidosis.

Step by step solution

01

About Acidosis

  • Acidosis occurs when the pHof the blood falls below the normal value ( pH of blood 7.4
  • The pH of substances that are a potential source of hydrogen tends to decrease.
02

Define why metabolic acidosis results accumulation of some citric acid cycle intermediates.

  • Blood functions as a buffer, allowing the pH value to be maintained.
  • However, a disruption in its blood buffer system can cause a drop in pH, which is referred to as acidosis.
  • In severe circumstances, acidosis can be lethal. For metabolism, the citric acid cycle is critical.
  • It produces a number of hydrogen-ion-producing intermediates such as citric acid, a-ketoglutaric acid, succinic acid, fumaric acid, malic acid, and oxalic acid.
  • These substances are acids that, if collected, can cause acidosis.

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Most popular questions from this chapter

Which compounds would accumulate in an individual with beriberi

(caused by thiamine deficiency)?

Which steps of the citric acid cycle regulate flux through the cycle?

Explain why an individual with a deficiency of pyruvate dehydrogenase phosphatase (PDP) is unable to tolerate exercise.

Question: Anaplerotic reactions permit the citric acid cycle to supply intermediates to biosynthetic pathways while maintaining the proper levels of cycle intermediates. Write the equation for the net synthesis of citrate from pyruvate.

What cofactors are required? Which of these are prosthetic groups?
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