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Chapter 18: Q34P (page 628)

The antidiabetes drug metformin inhibits 3-phosphoglycerol dehydrogenase. How would this affect ATP production by mitochondria?

Short Answer

Expert verified

The drug will decrease the synthesis of ATP in mitochondria.

Step by step solution

01

Enzyme 3-phosphoglycerol dehydrogenase

Glycerol-3-phosphate dehydrogenase or 3-phosphoglycerol) catalyzes the conversion of dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate.

02

Glycerol-3-phosphate shuttle

In yeast, plants, and animals, the glycerol-3-phosphate (G-3-P) shuttle is a critical mechanism for transporting cytosolic reducing equivalents into mitochondrial oxidative phosphorylation. The glycerol-3-phosphate shuttle allows NADH (produced in the cytoplasm during glycolysis) to contribute to the oxidative phosphorylation pathway (in the mitochondria) to produce ATP.

03

Effect of metformin

The synthesis of ATP in mitochondria would be reduced if metformin inhibited 3-phosphoglycerol dehydrogenase as the conversion of dihydroxyacetone phosphate (DHAP) to glycerol-3-phosphate is inhibited that shuttles NADH from cytoplasm to mitochondria for oxidative phosphorylation.

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Most popular questions from this chapter

Sketch the O2-consumption curves obtained for the mitochondria in Problem 29 when

(a) CN- is added at t=2and succinate is added at t=2and

(b) oligomycin (which binds to F0 and prevents ATP synthesis) is added at t=1 and DNP is added at t=2.

What does the Q cycle accomplish in each of its two rounds?

For the mitochondrial membrane described in Problem 31, how many protons must be transported to provide enough free energy for the synthesis of 1 mol of ATP (assuming standard biochemical conditions)?

Question: Dicyclohexylcarbodiimide (DCCD) is a reagent that reacts with Asp

or Glu residues.

Explain why the reaction of DCCD with the c subunits of F1F0-ATPase

blocks its ATP-synthesizing activity.

Vitamin K (Section 9-1F) is the cofactor for an enzyme that post translationally modifies certain proteins. It also functions as an electron carrier in some prokaryotes and may play a similar role in mitochondria. At what point in the mitochondrial electron-transport chain would vitamin K act?
See all solutions

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