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Chapter 12: Q6. (page 373)

Why can't an enzyme have a kcatKM value greater than 109M‐1s‐1?

Short Answer

Expert verified

The kcatKMvalue cannot be greater than 109M‐1s‐1 because this value is near the diffusion-controlled limit.

Step by step solution

01

Introduction

Enzymes are biological catalysts that catalyze chemical reactions. These are proteins that minimize the activation energy required to initiate chemical reactions.

02

Enzyme has a greater value

This rate cannot be faster than the diffusion-controlled encounter of an enzyme and its substrate. No enzyme can have a diffusion limit greater than 109M‐1s‐1, and this enzyme is working with maximum efficiency.

Thus, no enzyme can have kcatKM greater than the value 109M‐1s‐1.

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Most popular questions from this chapter

Write the rate equations for a first-order and a second-order reaction.

How can inhibitor binding to an enzyme be quantified?

Molecule A is the substrate for enzyme X. Which is more likely to be a competitive inhibitor of enzyme X: molecule B or molecule C? Explain.

What distinguishes an inhibitor from an inactivator?

Enzyme Acatalyzes the reactions S to P and has a KM of 50μMand a Vmaxof 100nMs‐1. Enzyme Bcatalyzes the reaction S→Q and has a KM of 5mMand a Vmax of 120nMs‐1. When 100μM of S is added to a mixture containing equivalent amounts of enzymes A andB , after 1minute which reaction product will be more abundant: P or Q?
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