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Chapter 15: Q14P (page 521)

What is the advantage of activating pyruvate kinase with fructose-1, 6-bisphosphate?

Short Answer

Expert verified

Fructose-1,6-bisphosphate acts as a feed-forward for the pyruvate kinase.

Step by step solution

01

Glycolysis

One molecule of glucose is transformed into two molecules of pyruvate during the process known as glycolysis. Glycolysis is a series of ten enzyme-catalyzed reactions. Overall, 2 ATP is created; throughout this process, 2 NAD+ is converted to 2 NADH.

02

Advantage of activating pyruvate kinase with Fructose-1,6-bisphosphate

The result of the third glycolysis step is fructose-1, 6-bisphosphate, which activates pyruvate kinase. FBP is a feed-forward stimulant in a glycolytic pathway intermediate because it increases allosteric activation and pyruvate kinase activity as its concentration increases.

Hence, the final six stages of glycolysis are pushed forward towards completion by this regulatory mechanism.

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Most popular questions from this chapter

Describe the three possible fates of pyruvate.

Write the reactions of glycolysis, showing the structural formulas of the intermediates and the names of the enzymes that catalyze the reactions.

Compare the ATP yield of three glucose molecules that enter glycolysis and are converted to pyruvate with that of three glucose molecules that proceed through the pentose phosphate pathway such that their carbon skeletons (as two F6P and one GAP) re-enter glycolysis and are metabolized to pyruvate.

Consider the pathway for catabolizing galactose. What are the potential control points for this pathway?

Draw the enediolate intermediate of the ribulose-5-phosphate isomerase reaction (Ru5P → R5P).
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