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Chapter 14: Q20P (page 476)

Why do DNA chips often contain segments derived from cDNA rather than genomic DNA segments?

Short Answer

Expert verified

Non-coding sections are not found in cDNA.

Step by step solution

01

Definition of DNA

Deoxyribonucleic acid is a polymer made of two polynucleotide chains that coil around one another to create a double helix and which contains the genetic material necessary for all known creatures, including many viruses, to develop, function, grow, and reproduce.Nucleic acids include DNA and ribonucleic acid.

02

Explanation

An RNA transcript's or the DNA encoding it's introns are non-coding segments that are spliced off before the RNA molecule is translated into a protein. Exons are the regions of DNA (or RNA) that code for proteins.

The presence of introns and exons in cDNA makes it a better choice for DNA chips than genomic DNA. Hence, non-coding DNA sections such as introns and exons are worthless in DNA chips.

Therefore, non-coding sections do not exist in cDNA.

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Most popular questions from this chapter

Methanogens are prokaryotes that produce methane according to the net equation

H2+ CO2→CH4+ 2H2O

Some bacteria consume methane according to the net equation CH4+ SO42 -→HCO3-+ HS-+H2O

(a) Classify these two types of bacteria as autotrophic or heterotrophic.

(b) Explain why the two types of bacteria are often found associated with each other.

What are the metabolic roles of the coenzymes NAD+ and FAD?

Describe how information about an organism’s genome can be used to assess and manipulate its metabolic activities.

In the partial reactions shown below, is the reactant undergoing oxidation or reduction?

Question:Biochemists studying cellular activity can quantify RNA sequences by converting them to DNA sequences that can be amplified via PCR (Section 3-5C), and they can quantify proteins by engineering the corresponding genes to include green fluorescent protein (Box 4-3). Explain why metabolites cannot be assessed using these same approaches.
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