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Chapter 23: Q15P (page 829)

Is trimethoprim a mechanism-based inhibitor of bacterial dihydrofolate reductase?

Short Answer

Expert verified

Trimethoprim is not a mechanism-based inhibitor of bacterial DHFR because it is a reversible inhibitor.

Step by step solution

01

Trimethoprim

Trimethoprim is an antifolate, a substance that prevents folate cofactors from working properly.It binds to dihydrofolate reductase (DHFR) and inhibits its activity.

02

Trimethoprim is a mechanism-based inhibitor of bacterial dihydrofolate reductase or not

The irreversible inhibition of enzymes by substrate analogs is known as mechanism-based inhibition in biochemistry. As trimethoprim is a reversible inhibitor, it can be said to be a mechanism-based inhibitor of bacterial DHFR.

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Most popular questions from this chapter

Why is dATP toxic to mammalian cells?

6-Mercaptopurine (Box 23-2), after its conversion to the corresponding nucleotide through salvage reactions, is a potent competitive inhibitor of IMP in the pathways for AMP and GMP biosynthesis. It is therefore a clinically useful anticancer agent. The chemotherapeutic effectiveness of 6-mercaptopurine is enhanced when it is administered with allopurinol. Explain the mechanism of this enhancement.

Compare the pathways of purine and pyrimidine nucleotide synthesis with respect to (a) precursors, (b) energy cost, (c) acquisition of the ribose moiety, and (d) number of enzymatic steps.

What is the role of NADPH in the formation of thymidylate?

List the starting materials and cofactors required for IMP biosynthesis.
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