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Chapter 23: Q17P (page 829)

Is allopurinol a mechanism-based inhibitor of xanthine oxidase?

Short Answer

Expert verified

Allopurinol is a mechanism-based inhibitor of xanthine oxidase because its oxidation product irreversibly inhibits the enzyme.

Step by step solution

01

Definition of Concept

Alloxanthine is produced when allopurinol is oxidized by xanthine oxidase.

02

Step 2:Explain the allopurinol is a mechanism-based inhibitor of xanthine oxidase or not

Alloxanthine binds irreversibly to a reduced form of xanthine oxidase, inactivating the enzyme.

A mechanism-based inhibitor is a molecule that goes through enzyme activity and produces an irreversible inhibitor of the enzyme.

Therefore, the allopurinol is a mechanism-based inhibitor of xanthine oxidase because its oxidation product irreversibly inhibits the enzyme.

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