Chapter 23: Q3P (page 828)
How does 2-azahypoxanthine, a fungal product that stimulates plant growth, differ from guanine?
Short Answer
Nitrogen is a part of the ring structure of 2-azahypoxanthine in the place of a second carbon of the guanine.
Chapter 23: Q3P (page 828)
How does 2-azahypoxanthine, a fungal product that stimulates plant growth, differ from guanine?
Nitrogen is a part of the ring structure of 2-azahypoxanthine in the place of a second carbon of the guanine.
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Get started for free6-Mercaptopurine (Box 23-2), after its conversion to the corresponding nucleotide through salvage reactions, is a potent competitive inhibitor of IMP in the pathways for AMP and GMP biosynthesis. It is therefore a clinically useful anticancer agent. The chemotherapeutic effectiveness of 6-mercaptopurine is enhanced when it is administered with allopurinol. Explain the mechanism of this enhancement.
The compound shown here is being tested as an anticancer agent.
(a) Explain why it inhibits CTP production.
(b) Explain why it also inhibits phospholipid synthesis.
Why is gout more prevalent in populations that eat relatively large amounts of meat?
What is the function of the purine nucleotide cycle?
What is the role of thioredoxin and NADPH in the formation of deoxyribonucleotides?
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