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Chapter 23: Q7CP (page 812)

How are CTP and UTP derived from UMP?

Short Answer

Expert verified

The synthesis of CTP from UTP is as follows:

UTP+Glutamine+ATP+H2O→CTPsynthaseCTP+Glutamate+ADP+Pi

The synthesis of UTP from UMP is as follows:

Step by step solution

01

Pyrimidines

Pyrimidines are a type of nitrogenous bases used to form deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The bases included in this category are uracil, thymine, and cytosine.

02

Synthesis of UTP from UMP

The nucleotide uridine triphosphate is synthesized from uridine monophosphate in two enzymatic steps. These steps are as follows:

03

Synthesis of CTP from UTP

The synthesis of cytidine triphosphate (CTP) occurs from UTP in one enzymatic step, which is:

UTP+Glutamine+ATP+H2O→CTPsynthaseCTP+Glutamate+ADP+Pi

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Most popular questions from this chapter

A nucleotide derivative that may have intracellular signaling activity is synthesized fromby the removal of the nicotinamide group and addition of an acetyl group at the 2′ position of the ribose attached to ADP. Draw its structure.

Why does von Gierke’s glycogen storage disease (Box 16-2) cause symptoms of gout?

What is the role of NADPH in the formation of thymidylate?

Compare the pathways of purine and pyrimidine nucleotide synthesis with respect to (a) precursors, (b) energy cost, (c) acquisition of the ribose moiety, and (d) number of enzymatic steps.

Certain glutamine analogs irreversibly inactivate enzymes that bind glutamine. Identify the nucleotide biosynthetic intermediates that accumulate in the presence of those compounds.
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