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Chapter 28: Q8P (page 1080)
Explain why (b) Inactivation of both O2 and O3reduces repression – 70 fold.
In the lac operon, only O1is required for activation of repression O2 and O3inhibits repression.
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Describe how histone modifications can affect the structure of nucleosomes and the function of transcription factors.
Why does the lack opera include more than one operator sequence?
Question: Explain why a deficiency of the vitamin folic acid could lead to the undermethylation of histones and DNA.
Question: Red–green color blindness is caused by an X-linked recessive genetic defect. Hence females rarely exhibit the red–green colorblind phenotype but may be carriers of the defective gene. When a narrow beam of red or green light is projected onto some areas of the retina of such a female carrier, she can readily differentiate the two colors, but on other areas she has difficulty in doing so. Explain.
Question: Why is transcriptionally active chromatin 10 times more susceptible to cleavage by DNase I than transcriptionally silent chromatin?
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