Hemolytic di sease of the newborn is a risk during a subsequent pregnancy in which ___________. a. a type AB mother is carrying a type \(\mathrm{O}\) fetus b. a type \(O\) mother is carrying a type \(A B\) fetus c. an \(\mathrm{Rh}^{+}\) mother is carrying an \(\mathrm{Rh}^{-}\) fetus d. an \(\mathrm{Rh}^{-}\) mother is carrying a second \(\mathrm{Rh}^{+}\) fetus

Short Answer

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a. A type AB mother carrying a type O fetus b. A type O mother carrying a type AB fetus c. An Rh+ mother carrying an Rh- fetus d. An Rh- mother carrying a second Rh+ fetus Answer: b and d

Step by step solution

01

Option A - Type AB mother carrying a type O fetus

Since type AB is a universal recipient (it has both A and B antigens on the red blood cells), while type O is a universal donor (with no antigen on the RBCs), therefore, this pregnancy doesn't pose a risk for HDN.
02

Option B - Type O mother carrying a type AB fetus

In this case, the mother has no antigens on her red blood cells (type O), and the fetus has both A and B antigens (type AB). The mother's antibodies could attack the fetus's red blood cells, causing HDN. This pregnancy is therefore at risk.
03

Option C - Rh+ mother carrying an Rh- fetus

In this situation, the Rh- fetus would not pose a threat to the Rh+ mother because her body would not produce antibodies against the Rh D antigen. This pregnancy doesn't pose a risk for HDN.
04

Option D - Rh- mother carrying a second Rh+ fetus

In this case, the Rh- mother has already been sensitized by the first Rh+ fetus (by her immune system being exposed to the Rh D antig en during the first pregnancy). She will produce antibodies against the Rh+ red blood cells of the subsequent fetus, causing HDN. This pregnancy is at risk for HDN. Therefore, the correct answer is: - b. a type O mother is carrying a type AB fetus. - d. an Rh- mother is carrying a second Rh+ fetus.

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