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Chapter 11: Problem 15

Which of the following statements is true about ON and OFF type retinal bipolar cells? a. ON bipolar cells possess KA/AMPA receptors and OFF bipolar cells possess NMDA receptors. b. ON bipolar cells possess NMDA receptors and OFF bipolar cells possess mGluR6. c. ON bipolar cells possess mGluR6 and OFF bipolar cells possess NMDA receptors. d. ON bipolar cells possess mGluR6 and OFF bipolar cells possess KA/AMPA receptors. e. ON bipolar cells possess KA/AMPA receptors and OFF bipolar cells possess mGluR6.

Short Answer

Expert verified
Answer: ON bipolar cells possess mGluR6 receptors, and OFF bipolar cells possess KA/AMPA receptors.

Step by step solution

01

Identifying the receptors present in ON and OFF bipolar cells

ON bipolar cells depolarize (become activated) in response to increments in light, while OFF bipolar cells depolarize in response to decrements in light. ON bipolar cells possess mGluR6 (metabotropic glutamate receptor 6) receptors, and OFF bipolar cells possess ionotropic glutamate receptors, like AMPA and kainate receptors (KA/AMPA).
02

Compare the options with the information from Step 1

Now, we'll go through the options one by one to find the correct statement. a. ON bipolar cells possess KA/AMPA receptors and OFF bipolar cells possess NMDA receptors. (Incorrect) b. ON bipolar cells possess NMDA receptors and OFF bipolar cells possess mGluR6. (Incorrect) c. ON bipolar cells possess mGluR6 and OFF bipolar cells possess NMDA receptors. (Incorrect) d. ON bipolar cells possess mGluR6 and OFF bipolar cells possess KA/AMPA receptors. (Correct) e. ON bipolar cells possess KA/AMPA receptors and OFF bipolar cells possess mGluR6. (Incorrect)
03

State the correct statement

The correct statement about ON and OFF type retinal bipolar cells is (d): ON bipolar cells possess mGluR6 receptors and OFF bipolar cells possess KA/AMPA receptors.

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