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Chapter 15: Problem 18

The chemokine co-receptors for HIV-infection infection are? a. CXCR7 and CCR1 b. CCR1 and \(\mathrm{CCR} 5\) c. CXCR4 and CCR1

Short Answer

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Answer: CCR1 and CCR5

Step by step solution

01

Understand chemokine co-receptors and their role in HIV infection

Chemokine co-receptors are proteins present on the surface of immune cells, like T-cells. They play a crucial role in the infection process of HIV. The virus binds to the main receptor (CD4) and a co-receptor to enter the target cells. Two major co-receptors for HIV infection are CCR5 and CXCR4.
02

Evaluate each given pair of chemokine co-receptors

Now let's evaluate each of the given pairs in the answer choices: a. CXCR7 and CCR1: CXCR7 is not known to be involved in HIV infection and CCR1 has a minor role in it. b. CCR1 and CCR5: Though CCR1 has a minor role in HIV infection, this option includes CCR5 which is one of the major co-receptors. c. CXCR4 and CCR1: This option includes CXCR4, which is a major co-receptor, but CCR1 has a minor role in HIV infection.
03

Choose the correct answer

Based on the evaluation of the given options, it is evident that none of the options include both major co-receptors (CCR5 and CXCR4); however, option (b) CCR1 and CCR5, comes the closest as it includes CCR5, which is one of the major co-receptors for HIV infection. Even though CCR1 has a minor role, this option is still the best choice among the given answers.

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Most popular questions from this chapter

Describe the two distinct means in which chemokine receptors participate in the pathogenesis of HAD.

The following cytokines serve as pro-inflammatory factors EXCEPT? a. IL-10 b. IL-1 c. IFN- d. IL-6

Which of the following statements about chemokines is correct? a. Chemokines and chemokine receptors play a significant role in pathogenesis of inflammatory disorders, such as HIV-1 associated dementia. fractalkine (FKN, CX3CLI) are constitutively produced in the brain. c. Macrophage inhibitory proteins one alpha and one cyte chemotactic protein-1 (MCP-1, CCL2) could be induced by inflammatory stimuli in the CNS. d. All of the above are correct.

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