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Chapter 15: Problem 21

Which of the following is the most potent chemoattractant for monocytes and macrophages? a. CXCLl2 b. CXXXCL 3 c. \(\mathrm{CCL} 2\) d. CXCL8

Short Answer

Expert verified
a. CXCL12 b. CXXXCL3 c. CCL2 d. CXCL8 Answer: c. CCL2

Step by step solution

01

Understanding Chemokines

Chemokines are small proteins that are involved in cell migration and play major roles in the immune system. They can be classified into four families: C, CC, CXC, and CX3C, based on the position of the first two cysteine residues in their amino acid sequence.
02

Evaluating the given chemokines

Let's analyze the given options: a. CXCL12: It is a CXC chemokine and acts mainly on lymphocytes. b. CXXXCL3: This is not a valid chemokine nomenclature as it does not follow the C/CXC/CC/CX3C naming system. c. CCL2: It is a CC chemokine, also known as Monocyte Chemoattractant Protein-1 (MCP-1), known for its strong attraction towards monocytes and macrophages. d. CXCL8: Also a CXC chemokine, primarily targeting neutrophils.
03

Identifying the most potent chemoattractant

From the analyzed options, we can conclude that: -CXCL12 and CXCL8 are not potent chemoattractants for monocytes and macrophages as they act mainly on lymphocytes and neutrophils, respectively. -CXXXCL3 is not a valid chemokine name and thus cannot be a potent chemoattractant. -CCL2 (MCP-1) specifically attracts monocytes and macrophages and is the most potent chemoattractant among the given choices for these cell types.
04

Answer

Therefore, the most potent chemoattractant for monocytes and macrophages is c. CCL2.

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