Which of the following myelin proteins is not involved in experimental neuritis? a. MAG b. P2 Protein c. P0 Protein d. MOG e. \(\mathrm{PMP} 22\)

The given options are: a. MAG (Myelin-Associated Glycoprotein) b. P2 Protein c. P0 Protein d. MOG (Myelin Oligodendrocyte Glycoprotein) e. PMP22 (Peripheral Myelin Protein 22) We need to determine which of these myelin proteins are not involved in experimental neuritis.

Examine the involvement of each of the listed proteins: a. MAG - This protein is mainly found in the central nervous system and plays a role in the interaction between axons and the myelin sheath. b. P2 protein - This protein is a myelin-specific protein present in the peripheral nervous system and has been implicated in experimental autoimmune neuritis (EAN). c. P0 protein - This protein is the most abundant myelin protein in the peripheral nervous system, and it has been found to be involved in experimental neuritis. d. MOG - This protein is mainly found in the central nervous system, and it has been implicated in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. e. PMP22 - This protein plays a role in peripheral nerve myelination, and mutations in this gene have been associated with various peripheral neuropathies, including Charcot-Marie-Tooth disease.

From our analysis in step 2, we can now identify the protein not involved in experimental neuritis: d. MOG (Myelin Oligodendrocyte Glycoprotein) - This protein is implicated in experimental autoimmune encephalomyelitis (EAE) and not experimental neuritis. So, the correct answer is (d) MOG.