Chapter 19: Problem 8

Which is the correct explanation for "onion bulb" formation in CIDP? a. Macrophages phagocytose myelin debris b. Abundant T-cell apoptosis c. Repetitive De- and Remyelination with Schwann cell proliferation d. Nitric oxide release e. Genetic myelin deficiency

Short Answer

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Answer: The primary cause of onion bulb formation in CIDP is repetitive demyelination and remyelination with Schwann cell proliferation.

Step by step solution

Introduction to Onion Bulb Formation

Onion bulbs are a histopathological feature seen in CIDP, characterized by concentric layers of Schwann cells around axons as a result of recurrent demyelination and remyelination.

Option a: Macrophages Phagocytose Myelin Debris

Macrophages play a role in the clearance of myelin debris after demyelination but do not directly contribute to onion bulb formation.

Option b: Abundant T-Cell Apoptosis

T-cell apoptosis is a process that takes place during the immune response, but it is not a primary cause of onion bulb formation in CIDP.

Option c: Repetitive De- and Remyelination with Schwann Cell Proliferation

The repetitive demyelination and remyelination in CIDP lead to onion bulb formation. This process involves the proliferation of Schwann cells, which try to repair the damaged myelin sheath by forming multiple layers around the affected axons.

Option d: Nitric Oxide Release

Nitric oxide is an important signaling molecule involved in many physiological processes, but it is not related to onion bulb formation in CIDP.

Option e: Genetic Myelin Deficiency

While genetic myelin deficiencies may be the cause of some demyelinating diseases, CIDP is primarily an autoimmune disorder and is not directly caused by a genetic myelin deficiency.

Correct Explanation for Onion Bulb Formation in CIDP

Based on the above analysis, the correct explanation for onion bulb formation in CIDP is option c, which states "Repetitive De- and Remyelination with Schwann cell proliferation." Therefore, the answer is c.

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Which is the correct explanation for "onion bulb" formation in CIDP? a. Macrophages phagocytose myelin debris b. Abundant T-cell apoptosis c. Repetitive De- and Remyelination with Schwann cell proliferation d. Nitric oxide release e. Genetic myelin deficiency

Short Answer

Step by step solution

Introduction to Onion Bulb Formation

Option a: Macrophages Phagocytose Myelin Debris

Option b: Abundant T-Cell Apoptosis

Option c: Repetitive De- and Remyelination with Schwann Cell Proliferation

Option d: Nitric Oxide Release

Option e: Genetic Myelin Deficiency

Correct Explanation for Onion Bulb Formation in CIDP

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