Chapter 21: Problem 17

Thalidomide is receiving new interest for use in some autoimmune conditions. What is the history and concern for its use?

Short Answer

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Answer: The main historical events include its introduction in the 1950s as a sedative and treatment for morning sickness, the discovery of its teratogenic effects causing severe birth defects in the 1960s, and its re-emergence for use in autoimmune conditions and cancer treatment. The main concerns revolve around its potential to cause significant birth defects, which led to strict regulations on its use, mandatory contraception, and pregnancy testing, and ongoing concerns about its safety in settings where regulations may be difficult to enforce.

Step by step solution

Learn and Understand the History of Thalidomide

Thalidomide was first introduced in the 1950s as a sedative and was later used to treat morning sickness in pregnant women. However, it was found to cause severe birth defects, leading to its withdrawal from the market in the early 1960s. Since then, it has re-emerged for use in some autoimmune conditions and cancer treatment, but concerns have remained about its use.

Understand the Concerns About Thalidomide

The primary concern with thalidomide use is its teratogenic effects, or the potential to cause severe birth defects. This side effect was discovered in the 1960s, where it was found to be responsible for thousands of birth defects, including limb malformations and other severe disabilities. These concerns have led to strict regulations on its use and the need to carefully consider its benefits and risks.

Learn About Thalidomide's New Uses

Thalidomide has been reintroduced for use in certain medical conditions due to its immunosuppressive and anti-inflammatory properties. It has been used to treat a variety of autoimmune conditions, such as erythema nodosum leprosum (ENL), a reaction to the bacterium that causes leprosy. Additionally, it has been used as a treatment for multiple myeloma, a type of blood cancer.

Understand the Regulations for Thalidomide Use

In response to the history and concerns surrounding thalidomide, strict regulations have been put in place to minimize the risks associated with its use. These regulations often require both physicians and patients to be registered before being able to prescribe or use the drug. Additionally, mandatory contraception and pregnancy testing are often required for women of childbearing age to prevent birth defects.

Know the Ongoing Concerns Around Thalidomide

Despite the regulations and new uses for thalidomide, concerns about its safety remain. Critics argue that the potential risks of the drug might outweigh its benefits, particularly in settings where strict regulations may be challenging to enforce. It's crucial that patients and healthcare providers are aware of thalidomide's history, its possible side effects, and the current restrictions and guidelines for its use, to make informed decisions.

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Thalidomide is receiving new interest for use in some autoimmune conditions. What is the history and concern for its use?

Short Answer

Step by step solution

Learn and Understand the History of Thalidomide

Understand the Concerns About Thalidomide

Learn About Thalidomide's New Uses

Understand the Regulations for Thalidomide Use

Know the Ongoing Concerns Around Thalidomide

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