Name the three products derived from proopiomelanocortin (POMC) for which evidence is the strongest supporting involvement in regulating immune system function.

Proopiomelanocortin (POMC) is a large precursor protein that is cleaved into several smaller peptide hormones that play diverse roles in the body. These hormones are involved in different physiological processes, including the immune response regulation, pigmentation, energy homeostasis, and stress response.

POMC is cleaved into several biologically active peptides, including adrenocorticotropic hormone (ACTH), α-melanocyte-stimulating hormone (α-MSH), β-endorphin, and others. Each peptide has specific biological roles and functions.

Based on the current literature and research, the three POMC-derived products with the strongest evidence supporting their involvement in immune system regulation are: 1. Adrenocorticotropic hormone (ACTH) 2. α-melanocyte-stimulating hormone (α-MSH) 3. β-endorphin

1. Adrenocorticotropic hormone (ACTH): ACTH is mainly known for its role in stimulating cortisol production in the adrenal cortex. Cortisol, a glucocorticoid hormone, plays a crucial role in regulating immune system function by controlling inflammation and modulating the immune response. 2. α-melanocyte-stimulating hormone (α-MSH): α-MSH has anti-inflammatory and immunomodulatory properties. It exerts its effects by binding to melanocortin receptors on immune cells, such as macrophages and lymphocytes, leading to suppression of inflammation and promotion of anti-inflammatory cytokine production. 3. β-endorphin: β-endorphin is an opioid peptide that has immunosuppressive effects. Studies suggest that it can suppress the immune response by reducing the release of pro-inflammatory cytokines and inhibiting the activation and proliferation of immune cells.