Chapter 21: Problem 6

Which neuropeptide is antiinflammatory when activating the HPA axis but is proinflammatory when released locally by immune cells? a. \(\mathrm{ACTH}\) b. CRH c. \(\beta\)-endorphin d. nociceptin e. \(\gamma-\mathrm{MSH}\)

Short Answer

Expert verified

Answer: (b) CRH

Step by step solution

Understand the question

The student needs to find the neuropeptide that acts as an anti-inflammatory agent when it activates the HPA axis but becomes pro-inflammatory when released locally by immune cells.

Review the options

Consider the options provided: a. \(\mathrm{ACTH}\) b. CRH c. \(\beta\)-endorphin d. nociceptin e. \(\gamma-\mathrm{MSH}\)

Identify the anti-inflammatory neuropeptide

CRH (corticotropin-releasing hormone) is the neuropeptide that is anti-inflammatory when activating the HPA (hypothalamic-pituitary-adrenal) axis. It regulates the stress response.

Check if the identified neuropeptide is pro-inflammatory when released locally

CRH also acts as a pro-inflammatory agent when released locally in immune cells. It regulates the inflammatory response.

Select the correct option

The correct answer is option (b) CRH, as it meets both criteria mentioned in the question.

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Which neuropeptide is antiinflammatory when activating the HPA axis but is proinflammatory when released locally by immune cells? a. \(\mathrm{ACTH}\) b. CRH c. \(\beta\)-endorphin d. nociceptin e. \(\gamma-\mathrm{MSH}\)

Short Answer

Step by step solution

Understand the question

Review the options

Identify the anti-inflammatory neuropeptide

Check if the identified neuropeptide is pro-inflammatory when released locally

Select the correct option

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